Table 2. Description of Corticosteroid Use Stratified by Treatment Group.
Treatment group | Prolonged corticosteroid use | New anti-TNF agent use | P value | ||
---|---|---|---|---|---|
Median (IQR) | Mean (SD) | Median (IQR) | Mean (SD) | ||
Crohn disease | |||||
Budesonide, mg | |||||
0-12 mo Before entry | 5.3 (0-9.0) | 4.4 (4.3) | 0 | 0.5 (2.0) | <.001 |
1-6 mo After entry | 6.0 (0-9.0) | 4.8 (4.2) | 0 | 0.3 (1.7) | <.001 |
7-12 mo After entry | 0 (0-6.0) | 2.6 (3.9) | 0 | 0.4 (1.8) | <.001 |
Systemic Corticosteroid, mg prednisone equivalent | |||||
0-12 mo Before entry | 0 (0-24.5) | 13.4 (17.9) | 0 (0-9.5) | 8.3 (22.4) | <.001 |
1-6 mo After entry | 0 (0-22.3) | 12.8 (18.6) | 0 | 6.6 (45.8) | <.001 |
7-12 mo After entry | 0 | 4.7 (12.2) | 0 | 3.5 (14.2) | .06 |
Ulcerative colitis | |||||
Budesonide, mg | |||||
0-12 mo Before entry | 0 | 1.2 (3.0) | 0 | 0.3 (1.6) | <.001 |
1-6 mo After entry | 0 | 1.3 (3.0) | 0 | 0.3 (1.7) | <.001 |
7-12 mo After entry | 0 | 0.6 (2.1) | 0 | 0.4 (2.1) | .10 |
Systemic corticosteroid, mg prednisone equivalent | |||||
0-12 mo Before entry | 25.0 (14.3-35.0) | 24.8 (17.4) | 0 (0-21.5) | 11.3 (16.7) | <.001 |
1-6 mo After entry | 23.3 (13.0-35.9) | 25.1 (18.8) | 0 (0-19.3) | 10.6 (19.0) | <.001 |
7-12 mo After entry | 0 (0-15.4) | 9.0 (15.1) | 0 | 4.2 (12.2) | <.001 |
Abbreviations: IQR, interquartile range; TNF, tumor necrosis factor.