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. 2021 Mar 1;4(3):e210313. doi: 10.1001/jamanetworkopen.2021.0313

Table 2. Description of Corticosteroid Use Stratified by Treatment Group.

Treatment group Prolonged corticosteroid use New anti-TNF agent use P value
Median (IQR) Mean (SD) Median (IQR) Mean (SD)
Crohn disease
Budesonide, mg
0-12 mo Before entry 5.3 (0-9.0) 4.4 (4.3) 0 0.5 (2.0) <.001
1-6 mo After entry 6.0 (0-9.0) 4.8 (4.2) 0 0.3 (1.7) <.001
7-12 mo After entry 0 (0-6.0) 2.6 (3.9) 0 0.4 (1.8) <.001
Systemic Corticosteroid, mg prednisone equivalent
0-12 mo Before entry 0 (0-24.5) 13.4 (17.9) 0 (0-9.5) 8.3 (22.4) <.001
1-6 mo After entry 0 (0-22.3) 12.8 (18.6) 0 6.6 (45.8) <.001
7-12 mo After entry 0 4.7 (12.2) 0 3.5 (14.2) .06
Ulcerative colitis
Budesonide, mg
0-12 mo Before entry 0 1.2 (3.0) 0 0.3 (1.6) <.001
1-6 mo After entry 0 1.3 (3.0) 0 0.3 (1.7) <.001
7-12 mo After entry 0 0.6 (2.1) 0 0.4 (2.1) .10
Systemic corticosteroid, mg prednisone equivalent
0-12 mo Before entry 25.0 (14.3-35.0) 24.8 (17.4) 0 (0-21.5) 11.3 (16.7) <.001
1-6 mo After entry 23.3 (13.0-35.9) 25.1 (18.8) 0 (0-19.3) 10.6 (19.0) <.001
7-12 mo After entry 0 (0-15.4) 9.0 (15.1) 0 4.2 (12.2) <.001

Abbreviations: IQR, interquartile range; TNF, tumor necrosis factor.