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. 2021 Feb 17;10(2):439. doi: 10.3390/foods10020439

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathological changes in the liver of rats exposed to ST-99. Normal hepatic parenchyma is observed in negative control group (A). Detail of hepatic cordons of rat exposed to the positive control (B), showing glycogenic degeneration (arrow) and abundant polyploid hepatocytes (circle). Rats exposed to 90 and 180mg/kg ST-99 showed an apparently normal liver parenchyma (C,D). Rats exposed to 360 mg/kg ST-99 exhibited slight presence hepatic apoptosis throughout the lobule (circle) and glycogenic degeneration (arrow) (E,F).