Table 1.
Micronucleus assay results in male (♂) and female (♀) rats. Bone marrow cytotoxicity expressed as polychromatic erythrocytes (PCE) among total erythrocytes (normochromatic erythrocytes (NCE) + PCE), ratio PCE among NCE, and the micronuclei induction expressed as % micronucleus (MN).
| Groups | Sex | n | Doses | PCE/NCE | PCE/Total | % MN |
|---|---|---|---|---|---|---|
| Negative Control | ♂ | 5 | 1.15 ± 0.17 | 0.53 ± 0.04 | 0.87 ± 0.08 | |
| ♀ | 5 | 1.78 ± 0.10 | 0.64 ± 0.03 | 0.99 ± 0.08 | ||
| Solvent Control | ♂ | 5 | 1.09 ± 0.19 | 0.51 ± 0.04 | 0.91 ± 0.16 | |
| ♀ | 5 | 2.35 ± 0.73 | 0.69 ± 0.07 | 1.03 ± 0.07 | ||
| Positive Control | ♂ | 3 | 200 mg/kg | 0.50 ± 0.08 ** | 0.33 ± 0.03 * | 2.35 ± 0.06 *** |
| ♀ | 3 | 0.68 ± 0.36 ** | 0.39 ± 0.13 * | 2.39 ± 0.05 *** | ||
| ST-99 extract | ♂ | 5 | 90 mg/kg b.w. | 0.94 ± 0.49 | 0.46 ± 0.12 | 0.86 ± 0.12 |
| ♀ | 5 | 1.12 ± 0.39 | 0.51 ± 0.08 | 0.89 ± 0.14 | ||
| ♂ | 5 | 180 mg/kg b.w. | 0.90 ± 0.17 | 0.46 ± 0.04 | 0.85 ± 0.05 | |
| ♀ | 5 | 1.16 ± 0.57 | 0.51 ± 0.10 | 0.93 ± 0.09 | ||
| ♂ | 5 | 360 mg/kg b.w. | 0.84 ± 0.38 | 0.43 ± 0.12 | 0.89 ± 0.19 | |
| ♀ | 5 | 1.32 ± 0.22 | 0.56 ± 0.04 | 0.94 ± 0.17 |
All values are expressed as mean ± SD. The significant levels observed are * p < 0.05, ** p < 0.01, or *** p < 0.001.