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Schematic description of an aptamer Holliday Junction (Apt-HJ) designed for colon cancer treatment. (A) The structure of Apt-HJ, which was made of four ssDNA chains. Each ssDNA had a PD-L1 aptamer at the 3′ end and the sequence for HJ at the 5′ end. (B) Schematic illustration of Apt-HJ’s binding to PD-L1 on the surface of tumor cells for blockade of PD-L1/PD-1 interaction.
