Figure 8.

In vivo antitumor study with CT26-bearing BALB/c mice (n = 7). CT26 tumor-bearing mice were treated with PBS, poly-A (control DNA sequence), poly-A-HJ, free PD-L1 aptamers, or Apt-HJ. The treatments were administered via intraperitoneal injection every two days, for a total of six injections (arrows). (A) Tumor volume and (B) body weights were recorded for various treatment groups. Stars indicate statistically significant differences (p < 0.05) between the Apt and the Apt-HJ groups, with p values of 0.011 and 0.020, respectively (raw data are presented in Table S1).