Table 1.
Classification of major MMPs and their substrate specificity for ECM components.
| Group | MMP | ECM Substrates |
|---|---|---|
| Collagenases | MMP-1 | Collagens (III>I>II, VII, X), gelatin, entactin, laminin, aggrecan, perlecan |
| MMP-8 | Collagens (I>II>III, VII, X), gelatin, fibronectin, aggrecan | |
| MMP-13 | Collagens (II>III>I, VII, X), gelatin, aggrecan, entactin | |
| Gelatinases | MMP-2 | Gelatin, collagen (IV-VI), fibronectin, elastin |
| MMP-9 | Gelatin, collagen (IV, V, VII, X, XIV, XVIII), fibrillin, elastin, osteonectin, fibronectin, elastin | |
| Stromelysins | MMP-3 | Gelatin, collagens (II, III, IV, V, IX, X, XI, XVIII), laminin, fibronectin, aggrecan, fibrin, elastin, perlecan |
| MMP-10 | Collagen (I, III-V), gelatin, elastin, aggrecan, proteoglycan | |
| MMP-11 | Fibronectin, gelatin, laminin, aggrecan | |
| Matrilysins | MMP-7 | Collagen (IV–X, XVIII), gelatin, laminin, aggrecan, fibronectin, vitronectin, fibrin, entactin, vitronectin |
| MMP-26 | Gelatin, collagen type IV, fibronectin, fibrin | |
| Metalloelastase | MMP-12 | Elastin, collagen (I, IV, XVIII), gelatin, laminin, vitronectin, fibronectin, proteoglycan |
| Membrane-type MMPs | MMP-14 | Gelatin, collagens (I, II, III), fibronectin, laminin, fibrin, perlecan |
| MMP-15 | Collagens (I, IV), perlecan, fibronectin, laminin, aggrecan, perlecan | |
| MMP-16 | Fibrin, gelatin, type III collagen, fibronectin, vitronectin, laminin | |
| MMP-17 | Gelatin, fibrin | |
| MMP-24 | Gelatin, fibronectin, laminin, proteoglycans |