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. 2021 Feb 18;22(4):2016. doi: 10.3390/ijms22042016

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CASR activation induces the YAP1 signaling in the CASR-HEK293A cell model. (a,b) Accumulation of YAP1 in the nuclear (a) or the cytosolic (b) fractions of CASR-HEK293A cells stimulated for 1 h with increasing concentrations of the CASR agonist R568 (* p = 0.003 by one-way ANOVA) was analyzed by Western blotting, and a representative blot is shown. (c) Expression of phosphorylated LATS1 (pLATS1), LATS1, and LATS2 in CASR-HEK23A cells treated with the indicated concentrations of R568 for 10 min; a representative Western blot is shown (* p = 0.006 vs. NT; ** p = 0.0003 vs. NT, by one-way ANOVA). Bars, mean ± SEM (n = 3) of the fold change with respect to untreated conditions (NT).