Table 1.
Genetic, biochemical, and clinical features of the series of parathyroid carcinomas (PCas) analyzed by immunohistochemistry for YAP1 expression. Cell division cycle 73 (CDC73), cell division cycle 73; MEN1, multiple endocrine neoplasia type 1; SCa, serum total calcium; PTH, plasma parathormone: Recur., tumor local recurrence; Metas., distant metastasis; WT, wildtype gene sequence. All samples were included in previous studies [25,47,48,49].
| PCa Sample | Germline/ Somatic |
CDC73 Mutation |
MEN1 Mutation |
SCa mg/dL |
PTH pg/mL |
Recur. | Metas. |
|---|---|---|---|---|---|---|---|
| PCa1 | Germline | c.518_521del4 | WT | 13.0 | 660 | yes | no |
| PCa2 | Germline | p.R415X | WT | 12.7 | 367 | no | yes |
| PCa3 | Germline/Somatic | WT | WT | 20.2 | 940 | no | no |
| PCa4 | Germline | WT | p.D418N | Na | na | no | no |
| PCa5 | Germline | c.685_688 delAGAG |
WT | 10.0 | 101 | yes | no |
| PCa6 | Germline | WT | p.Q166L/A167S | 11.8 | 160 | yes | no |