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. 2021 Feb 17;13(2):270. doi: 10.3390/pharmaceutics13020270

Figure 5.

Figure 5

Victim drug plasma concentration−time profiles of the modeled drug–drug interactions with carbamazepine as perpetrator drug. Predictions of the victim drug plasma concentrations during the (a) carbamazepine−alprazolam DDI [81], (b) carbamazepine−simvastatin DDI [7] (c) carbamazepine−bupropion DDI [8] and (d) carbamazepine−efavirenz DDI [10] are shown in comparison to observed data. Observed data are shown as dots ± SD (if available); predictions are shown as solid lines. Details on the study protocols and model simulations of all investigated DDI studies are provided in the Supplementary Materials. md: multiple dose, n: number of individuals, sd: single dose, tab: tablet.