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. 2021 Feb 18;13(4):857. doi: 10.3390/cancers13040857

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Ad.5-TCTV induces apoptosis and inhibits angiogenesis in vivo. MDA-MB 231 and mu-Hi-Myc PDX cancer cells were implanted subcutaneously in the lower and upper flanks of nude mice and the lower tumors were treated with eight intratumoral injections including solvent (mock treated control), Ad.5-E1A or Ad.5-CTV or Ad.5-TCTV. A total of five animals were studied in each group. Once the control animals’ tumors reached maximum allowable limit, tumors were collected, fixed in formalin, and embedded in paraffin. (A) Immunohistochemical (IHC) analysis of MDA-7/IL-24, adenovirus E1A, and Luciferase from tumor sections as indicated. (B) IHC analysis of Bcl-2 and CD-31 from tumor sections as indicated. Scale bar: 200 μM.