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. 2021 Feb 19;22(4):2050. doi: 10.3390/ijms22042050

Figure 2.

Figure 2

(A) Schematic representation of an RND efflux pump as a tripartite system consisting of cytoplasmic membrane transporter (CMT), outer membrane factor (OMF), and membrane fusion protein (MFP). (B) Phylogenetic tree of P. aeruginosa CMT listed in [65] and E. coli cusA/czcA depicted with dashed line. (C) Phylogenetic tree of P. aeruginosa OMF listed in [65] and E. coli cusC depicted with dashed lines; no close homolog was found for czcC in E. coli. (D) Phylogenetic tree of P. aeruginosa MFP listed in [65] and E. coli cusB depicted with dashed line; no close homolog was found for czcB in E. coli. Calculated with Clustal Omega and illustrated with iTOL [133,134].