Table 1.

Proteins involved in copper homeostasis in P. aeruginosa and E. coli. A reference indicates experimental evidence of copper homeostasis. * indicates a potential role in copper homeostasis based on the homology alignment or structural prediction of proteins found in other pseudomonad strains and bacteria. TF: transcription factor; MT: metallothionein; CYTO-C: cytoplasmic copper chaperone; 2CS: copper-sensing two-component systems; P-type: P-type copper ATPase; RND: resistance-nodulation-division-type transmembrane efflux pump; Peri C: periplasmic copper chaperone; MCO: multicopper oxidase; Sidero: siderophores; N/A: not applicable. Table adapted from [85].

	TF	MT	CYTO-C	2CS	P-Type	RND	Peri C	MCO	Sidero	Others
P. aeruginosa	cueR [86]	MT * [87]	copZ1 copZ2 [86,88]	copRS [89]	copA1 copA2 [90]	czcCBA *	ptrA [91] azurin [92]	pcoA [93]	PVD PCH [82,83,84]	pcoB * [94]
E. coli	cueR [95]	N/A	N/A	pcoRS [96] cusRS [97]	copA [93]	cusCFBA [98]	pcoE [99] pcoC [100] cusF [98]	pcoA [101] cueO [102]	Ybt [103]	cut [95] pcoB [104] pcoD [104] porins