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. 2021 Feb 18;22(4):2025. doi: 10.3390/ijms22042025

Figure 1.

Figure 1

Tumor formation of back skin was enhanced in CCL17 TG mice. Shaved back skin of wild-type (WT) and CCL17 transgenic (TG) mice was treated with injection of B16F1 cells or EL4 cells. The tumor size was calculated using the equation: L1 × L2, where L1 = longest diameter (mm) and L2 = shortest diameter (mm) and evaluated on days 4, 7, 10, and 14. (A) Phenotypical manifestation of back skin from WT and CCL17 TG mice 14 days after B16F1 cells injection (yellow circle). (B) Tumor sizes were significantly increased in CCL17 TG mice compared with those in WT mice on days 7, 10, and 14 after subcutaneous injection of B16F1 cells. (C) Tumor formation was also significantly promoted in CCL17 TG mice compared with that in WT mice on days 10 and 14 after injection of EL4 cells. Data are presented as mean ± SEM of three independent experiments (n = 6 for each group). * p < 0.05, ** p < 0.01, versus WT mice.