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. 2021 Feb 18;22(4):2025. doi: 10.3390/ijms22042025

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Downregulation of CXCL17 production in IL-4-stimulated normal human epidermal keratinocytes (NHEK) and decreased CXCL17 expression in patients with atopic dermatitis (AD). Expression of CXCL17 mRNA was assessed in NHEK cells treated with IL-4 stimulation. CXCL17 expression levels were evaluated in sera of patients with AD. (A) CXCL17 mRNA expression by NHEK was significantly attenuated by IL-4 stimulation. (B) Serum levels of CXCL17 in patients with AD were significantly decreased compared with normal controls. * p < 0.05.