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Generation of 5-hmdU and structures of pertinent SMUG1-targeted oxidative lesions. Chemical structures of SMUG1 lesions. (A) Formation of pertinent SMUG1 lesions: 5-hydroxymethyluracil (5-hmU) after oxidation of thymine by reactive oxygen species (ROS) or ten-eleven translocation (TET) enzymes. (B) Base pairings of SMUG1 target substrates. The hydroxyl moiety generated by ROS is highlighted in red.
