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Structure of SMUG1 highlighting the role of the wedge domain in catalysis. Crystal structure of Xenopus SMUG1 (A) The glycosylase (blue) bound to DNA (black) containing an abasic site with the damage recognition wedge (loop, light green; helix, dark green) with the free 5-hmdU (orange), PDB: 1OE6. (B) Key active site residues of SMUG1 (PDB: 1OE5), with Xenopus (black) and human (red) numberings; adapted from [8] with permission.
