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SMUG1 processes lesions within nucleosomes inefficiently. SMUG1 (A) excision activity and (B) kinetics on naked DNA and nucleosome core particle (NCP), from [14] with permissions. (C) Crystal structure of the NCP highlighting the (D) U:G wobble base pair lesion from [15] with permission. (E) SMUG1 excision kinetics (red) compared to the activity of other UDG glycosylases, UNG (black) TDG (blue, green) from [15] with permission.
