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The metastatic cascade in colorectal cancer: fate of circulating tumour cells and components of the pre-metastatic niche. Disseminated cancer cells from the primary tumour travel through the circulation and enter the liver via the hepatic portal vein along with tumour derived factors, bone marrow-derived dendritic cells (BMDCs), and immune cells that prime the liver microenvironment for the colonisation of circulating tumour cells (CTCs) into micro-metastases.
