Table 1.
CRC consensus molecular subtypes.
| CMS1 MSI Immune |
CMS2 Canonical |
CMS3 Metabolic |
CMS4 Mesenchymal |
|
|---|---|---|---|---|
| ~% CRC Cases | 14% | 37% | 13% | 23% |
| Key Characteristics | MSI High | MSI low | Mixed MSI | MSI low |
| Somatic copy number alteration (SNCA) low | SNCA high | SNCA low | SNCA high | |
| Hypermethylation | Hypermethylation | |||
| Significant immune infiltration | Stromal infiltration | |||
| Altered Pathways | DNA mismatch repair (PD1, PD-L1) | Wnt | Metabolic pathways | TGFβ |
| Jak/STAT | Myc | EMT | ||
| ECMremodeling | ||||
| Key Gene Mutations | BRAF | TP53 | KRAS | |
| PIC3CA |