Table 2.
Sterols’ concentrations in cystic fibrosis (CF) patients and healthy subjects (HS).
| Method | Clinical Parameters | CF Patients | HS | p |
|---|---|---|---|---|
| Median (1st–3rd Quartile) | ||||
| Chromatographic | Campesterol [μg/dL] | 292 (172–492) |
452 (363–514) |
0.0028 |
| β-sitosterol [μg/dL] | 165 (92–283) |
401 (319–507) |
<0.0001 | |
| Stigmasterol [μg/dL] | 9 (7–24) |
14 (12–19) |
ns. | |
| Lathosterol [μg/dL] | 480 (281–720) |
286 (235–435) |
0.0016 | |
| Enzymatic | Total cholesterol [mg/dL] | 135 (110–176) |
168 (147–185) |
0.0006 |
| HDL-C [mg/dL] | 49 (42–56) |
66 (53–67) |
<0.0001 | |
| LDL-C [mg/dL] | 66 (51–94) |
83 (75–105) |
0.0093 | |
| Ratio | Lathosterol/Campesterol | 1.73 (0.64–3.43) |
0.80 (0.48–0.99) |
0.0002 |
| Lathosterol/β-sitosterol | 2.93 (1.18–6.62) |
0.91 (0.54–1.15) |
<0.0001 | |
HDL-C—high-density lipoprotein cholesterol. LDL-C—low-density lipoprotein cholesterol.