Table 4.
Sterol concentrations in subgroups of cystic fibrosis patients defined by different clinical parameters.
| Parameters | Sex | BMI [kg/m2] | CFTR Genotype | Exocrine Pancreatic Insufficiency | Liver Disease | Diabetes | P. aeruginosa | FEV1 [%] | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median 1st–3rd Quartiles |
Women | Men | ≤21 | >21 | Severe | Other | Yes | No | Yes | No | Yes | No | Yes | No | <80 | >80 |
| N | 33 | 22 | 28 | 27 | 32 | 23 | 48 | 7 | 26 | 29 | 9 | 46 | 37 | 18 | 39 | 16 |
| Campesterol [μg/dL] |
298.9 207.6–505.5 |
356.8 152.5–465.1 |
274.9 175.0–411.1 |
298.9 223.9–565.2 |
225.6 ***
160.2–308.3 |
549.8 ***
311.1–790.6 |
256.8 **
163.8–422.3 |
733.7 **
479.9–1015.0 |
251.8 157.6–402.8 |
309.5 227.2–599.2 |
221.9 166.3–292.4 |
307.1 195.6–587.2 |
257.3 166.3–431.3 |
360.7 221.9–587.2 |
301.5 199.4–492.0 |
257.3 152.6–52.0 |
| β–sitosterol [μg/dL] |
167.9 97.3–296.5 |
156.2 87.4–283.6 |
159.5 86.4–241.5 |
20.1.6 97.3–289.4 |
108.3 ***
81.1–210.2 |
273.3 ***
172.4–376.8 |
156.2 **
85.5–246.1 |
362.7 **
244.7–520.1 |
113.6 81.7–221.4 |
214.6 114.8–285.5 |
160.1 101.7–170.3 |
193.5 91.8–291.3 |
126.1 *
87.4–267.1 |
207.4 *
156.2–283.6 |
165.4 95.6–265.1 |
159.1 86.4–297,3 |
| Stigmasterol [μg/dL] |
10.4 7.7–23.9 |
9.1 7.0–23.7 |
12.7 8.5–24.1 |
8.2 7.2–23.5 |
9.0 7.2–23.5 |
9.8 7.6–23.7 |
8.4 7.2–23.0 |
20.9 9.8–27.6 |
9.2 7.5–20.9 |
8.8 7.2–23.8 |
5.9 5.0–6.8 |
9.2 7.4–23.8 |
12.1 8.4–24.6 |
7.8 6.2–9.5 |
9.1 7.1–23.0 |
8.4 7.8–24.5 |
| Lathosterol [μg/dL] |
543.3 *
414.8–814.2 |
381.7 *
253.3–531.5 |
448.3 242.5–618.7 |
569.3 388.9–790.1 |
489.7 263.0–735.4 |
476.5 260.9–704.8 |
486.5 300.1–739.4 |
472.8 287.7–506.1 |
505.8 292.9–722.7 |
480.1 317.1–717.5 |
314.6 199.1–468.5 |
493.0 372.1–731.5 |
480.2 257.0–696.4 |
493.0 372.1–819.1 |
432.9 *
258.8–604.4 |
696.4 *
510.1–814.3 |
| Total cholesterol [mg/dL] |
143.0 *
131.0–182.0 |
123.0 *
91.0–166.0 |
135.0 97.2–152.0 |
157.0 123.2–186.0 |
125.0 ***
94.0–136.0 |
184.0 ***
144.5–195.5 |
135.0 *
103.5–167.5 |
182.0 *
146.5–205.5 |
135.0 98.7–158.2 |
144.0 125.5–186.0 |
123.0 98.0–161.0 |
135.0 124.0–186.0 |
135.0 101.0–166.0 |
161.0 124.0–186.0 |
135.0 105.0–172.0 |
135.0 126.0–184.0 |
| HDL–C [mg/dL] | 51.0 43.0–57.0 |
47.0 37.8–55.3 |
45.0 34.8–58.0 |
49.5 44.0–55.0 |
44.5 **
33.3–51.5 |
54.5 **
48.3–57.8 |
48.0 41.5–55.0 |
53.0 50.5–57.5 |
46.5 35.3–55.5 |
49.5 43.0–55.5 |
48.0 37.0–59.0 |
49.0 42.0–55.5 |
48.0 36.0–54.0 |
51.0 47.0–56.0 |
47.0 36.5–56.0 |
51.5 47.0–58.5 |
| LDL–C [mg/dL] |
71.0 57.0–107.0 |
57.5 44.3–91.3 |
61.5 50.3–74.3 |
90.5 56.3–109.8 |
55.0 ***
42.5–69.5 |
95.0 ***
76.0–111.0 |
62.0 **
48.0–87.0 |
109.0 **
95.0–126.0 |
62.0 51.0–89.3 |
76.0 55.0–109.0 |
62.0 51.0–83.0 |
70.0 55.0–104.0 |
62.0 49.0–91.0 |
82.0 57.8–109.3 |
68.0 51.0–93.5 |
65.5 52.8–95.0 |
* p<0.05; ** p<0.01; *** p<0.001; HDL–C–high–density lipoprotein cholesterol; LDL–C–low–density lipoprotein cholesterol.