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. 2021 Feb 19;11(2):344. doi: 10.3390/diagnostics11020344

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hippo pattern in OC. (A) The expression level of the main genes, Hippo genes, upstream effectors (MST1/ STK4, MST2/STK3, LATS1/2), YAP/TAZ, and downstream genes (BBC3, TEAD1, SMAD2, TP53, and TP73) involved in Hippo signaling in OC (box plot representation using GEPIA, TT: tumor tissues, TN: normal tissues); (B) Heatmap of mRNA expression results by querying the interest genes with the default setting (z-score threshold of 2) generated using cBioPortal for ovarian serous cystadenocarcinoma (TCGA, PanCancer Atlas, 585 patients); (C) Gene-related changes in critical components of the Hippo pathways in OC. Mutational pattern for selected genes on the same patient cohort. (* p value ≤ 0.05).