Table 8.
Logistic regression analysis of PVT1, HOTAIR, NEAT1, MALAT1, PAI-1, and OPN to predict breast cancer risk in patients with fibroadenoma.
| Parameter (Fibroadenoma) | Coefficient (β) | SE | Wald (x2) | p-Value | Odds Ratio | 95% CI |
|---|---|---|---|---|---|---|
| Univariate Analysis | ||||||
| PVT 1 | 0.04 | 0.04 | 0.70 | 0.40 | 1.04 | 0.94–1.14 |
| HOTAIR | 1.03 | 0.35 | 8.67 | 0.003 * | 2.80 | 1.41–5.57 |
| NEAT1 | 0.11 | 0.15 | 0.54 | 0.45 | 1.12 | 0.82–1.53 |
| MALAT1 | 0.37 | 0.260 | 2.09 | 0.14 | 1.45 | 0.87–2.42 |
| PAI-1 | 0.13 | 0.04 | 7.60 | 0.006 * | 1.14 | 1.03–1.25 |
| OPN | 0.08 | 0.03 | 7.66 | 0.006 * | 1.09 | 1.02–1.15 |
| Multivariate Analysis | ||||||
| HOTAIR | 1.35 | 0.47 | 8.19 | 0.004 * | 3.88 | 1.53–9.81 |
| PAI-1 | 0.19 | 0.07 | 6.49 | 0.01 * | 1.21 | 1.04–1.40 |
| OPN | 0.12 | 0.05 | 6.76 | 0.009 * | 1.13 | 1.03–1.25 |
* Significance at p < 0.05; PVT1, plasmacytoma variant translocation 1 gene; HOTAIR, HOX transcript antisense; RNA; NEAT1, nuclear enriched abundant transcript 1; MALAT1, metastasis associated lung adenocarcinoma transcript 1; PAI-1, plasminogen activator inhibitor-1; OPN, osteopontin; SE, standard error.