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. 2021 Feb 17;22(4):1967. doi: 10.3390/ijms22041967

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Efficacy of um-PEA and LAC treatment on iNOS expression. Tissues obtained from CAR injected-animals exhibited positive immunostaining for iNOS (B,F), compared to the sham-treated animals (A,F). Um-PEA and LAC (5 mg/kg) treatment reduced this expression (E,F); this reduction was milder with CAR + LAC (100 mg/kg) plus, separate but consecutive, non-m-PEA (100 mg/kg) and CAR + non-m-PEA and LAC (1:1) (200 mg/kg) (data not shown). Other treatments did not display a significant decrease in iNOS expression (C,D,F, and data not shown). Black arrows indicate the positive staining for iNOS. Data are representative of at least three independent experiments. Values are means ± SEM. One-Way ANOVA test. *** p < 0.001 vs. sham; ^# p < 0.05 vs. CAR; ^## p < 0.01 vs. CAR; ^### p < 0.001 vs. CAR.