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(a) Crystallographic 3D structure of doxorubicin (gold) in complex with DNA (PDB ID: 151D), d(CGATCG) and (b) the anthracycline structure is strongly bound to DNA base pairs through multiple hydrogen bonds (HBs) depicted as green dotted lines; DNA-ligand representation was achieved using Biovia Discovery Studio 4.1 (Dassault Systems).
