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. 2021 Feb 19;22(4):2066. doi: 10.3390/ijms22042066

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IL-4 levels at different times after laser-induced ocular hypertension (OHT). (a) Variation over time in the IL-4 levels in the multiplex assay. The histogram shows the mean levels (±SD) of IL-4 (pg/mg) at days 1, 3, 5, 7, and 15 after laser OHT induction, in ocular hypertension eyes (OHT) and in contralateral eyes. The dashed line indicates the mean levels in naïve eyes. Statistical significance indicators: ** p < 0.01 vs. naïve; ++ p < 0.01 vs. OHT. (b) Immunohistochemical study of IL-4 expression in OHT eyes three days after unilateral laser-induced OHT. Retinal sections were immunolabeled with antibodies to IL-4 (green) and Iba-1 (red). Merge (yellow). The arrowheads indicate the co-expression of Iba-1 and IL-4 in OHT eyes. Abbreviations: OHT (ocular hypertension); IL-4 (interleukin 4); Iba-1 (ionized calcium-binding adaptor molecule 1).