Table 2.
Comparison of naive and natural, anticipatory and effector memory response.
| Characteristics | Naive | Natural Memory | Anticipatory Memory | Effector Memory |
|---|---|---|---|---|
| B cell types | B2 | B1 | BM | LLPC |
| T cell types | TN | Tγδ | TCM, TSCM | TEM, TRM |
| Activation state | Resting | Self-renewing | Resting | Active |
| Function | Replenishment, seeding new memory | Natural gatekeeper | Circulating surveillance | Terminally differentiated effector |
| Response type | Primary response | Maintenance | Secondary response | Maintenance |
| Proliferative capacity | High upon activation | Constant | High upon activation | No/limited |
| Time of protection | Slow | Immediate/quick | Medium | Immediate/quick |
| Efficiency | Medium | Low | Medium to high | High |
| Flexibility of repertoire | High | Limited | Medium | No/minimal |