Table 3.

Strengths and weaknesses of different vaccine types in memory response in addition to B cell-related memory.

Vaccine Type	Strength in Memory Response	Weakness in Memory Response
Attenuated	Multiple antigens CTL response Optimal helper T cell response, Parallel PRR activations
Inactivated	Multiple antigens Adjuvant determined helper T cell response Parallel PRR activations	Lack of CTL response Possibility of nonoptimal TH response May induce weaker response, may need booster
Subunit	Adjuvant determined helper T cell response	Lack of CTL response Adjuvant dependent Possibility of nonoptimal TH response Possibility of antigen sin May induce weaker response, may need booster
Conjugated	Adjuvant determined helper T cell response	Lack of CTL response Adjuvant dependent Possibility of nonoptimal TH response Possibility of antigen sin May induce weaker response, may need booster
Toxoid		Lack of CTL response (irrelevant) Adjuvant dependent Possibility of nonoptimal TH response (irrelevant) May induce weaker response, may need booster
VLP	CTL response Optimal helper T cell response Parallel PRR activations	Possibility of antigen sin The carrier-specific reaction may result in a weaker reaction
RNA	CTL response Helper T cell response PRR activations	Possibility of antigen sin May induce weaker response, may need booster
DNA	CTL response Helper T cell response	Possibility of antigen sin May induce weaker response, may need booster