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. 2021 Feb 19;10(4):867. doi: 10.3390/jcm10040867

Figure 3.

Figure 3

TLR2 and TLR7 expression in prognostically different CLL subgroups in refers to expression of ZAP-70 and mutational status of immunoglobulin heavy chain variable (IGHV) in bone marrow mononuclear cells (BMMC). (A) Higher expression of TLR2 in CLL patients with unmutated (UM) IGHV than in patients with IGHV mutation (MUT) (0.212 vs. 0.1795, p < 0.05). Each dot (UM IGHV) and triangle (MUT IGHV) represents an individual case. (B) Higher expression of TLR2 in ZAP-70+ patients compared to ZAP-70− (0.2225 vs. 0.1885, p = 0.0014). Each dot (ZAP-70+) and triangle (ZAP-70-) represents an individual case. (C) Higher expression of TLR7 in IGHV UM patients compared to IGHV MUT (0.549 vs. 0.407 p < 0.0361). Each square (UM IGHV) and rhombus (MUT IGHV) represents an individual case. (D) Higher expression of TLR7 in ZAP-70+ patients compared to ZAP-70− (0.694 vs. 0.424, p < 0.0001). Each square (ZAP-70-) and rhombus (ZAP-70+) represents an individual case.