Table 3.

Characteristics of genetic variants that influence skin-wrinkle risk selected by genome-wide association study.

Chr a	SNP	Position	Mi b	Ma c	ORs (95% CI) d	p-Value for ORs e	MAF f	p-Value for HWE g	Gene	Feature
7	rs1861003	55184849	G	A	0.282 (0.083–0.952)	4.14 × 10−2	0.1078	0.599	EGFR	intron
8	rs6469206	88072463	G	T	0.481 (0.244–0.949)	3.48 × 10−2	0.4752	0.4251	MMP16	intron
10	rs805698	104057158	T	C	11.49 (2.225–76.08)	4.40 × 10−3	0.1127	0.3557	COL17A1	missense
4	rs4697073	24799121	A	G	0.206 (0.045–0.949)	4.27 × 10−2	0.0546	1	SOD3	intron
20	rs1291206	63697816	A	G	2.76 (1.34–5.66)	5.71 × 10−3	0.3614	0.5168	TNFRSF6B	intron
1	rs6690493	12075469	G	A	0.189 (0.064–0.553)	2.38 × 10−3	0.2108	0.2295	TNFRSF8	intron
12	rs9658535	117219805	C	T	3.81 (1.42–10.2)	7.74 × 10−3	0.1765	0.7314	NOS1	intron

^a The position of the single nucleotide polymorphism (SNP) in the chromosome. ^b Minor allele; ^c major allele; ^d odds ratio for each genetic variant to influence wrinkle risk; ^e p value for odds ratios that have an association with wrinkle risk after adjusting for covariates including age and UV exposure. ^f minor allele frequency; ^g Hardy-Weinberg equilibrium. EGFR, epidermal growth factor receptor; MMP16, matrix metalloproteinase; COL17A1, collagen type XVII alpha 1 chain; SOD3, superoxide dismutase 3; TNFRSF, tumor necrosis factor (TNF) receptor superfamily member; NOS1, nitric oxide synthase-1.