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Phage genetic modification strategy against bacteria. Phages are engineered to enhance the bactericidal efficacy by (A) expressing toxin proteins, including λ S105, Bgl II, ChpBK, Gef, and peptide 1018; (B) suppressing the SOS response (SOS) repair system by overexpressing repressor protein LexA [20]; (C) degrading and inhibiting the biofilm using DspB and AiiA, respectively; and (D) re-editing the phage tail fiber genes to expand the phage host range [25,26,27,28].
