Table 1.
Similarity of P31–43, viral ligands, and delay of the endocytic trafficking effects on Caco2 * cells, intestinal biopsies from CD patients ** and mice ***, on different pathways as indicated.
| Pathways | HRS Silencing * |
P31–43 * and ** | Loxorubine * | ATIs | Poly I:C *** |
|---|---|---|---|---|---|
|
Delay of vesicular
trafficking (EEA1, LAMP2, EGFR) |
YES | YES | YES | Not tested | Not tested |
|
Activation of innate
immunity (IL15, IL15Ralpha) |
YES | YES | YES | Yes | YES |
| Activation of inflammatory markers (NFkB and MAPK) | YES | YES | YES | Yes | YES |
|
TLRs
activation (MXA, Mydd 88, INF-alpha) |
YES | YES | YES | Yes | YES |