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. 2021 Feb 18;22(4):2003. doi: 10.3390/ijms22042003

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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nc886 suppresses the IRF3 pathway. (A) Luciferase assays as described in Figure 3A, except that Poly(I:C)-LMW was used. (B) Simplified image for RIG-I and TLR3 pathways. Solid arrows designate pathogen sensing by indicated proteins; dotted arrows designate signal transduction between indicated proteins, which often involves multiple other factors. (C) Luciferase assays as described in panel A. (D) Western blot of indicated proteins at 24 h after transfection of MAVS-expressing plasmid in combination with control (“mock”) or nc886-expressing plasmid. Three asterisks designate a p-value less than 0.001. “n.s.”: not significant.