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. 2021 Feb 19;22(4):2068. doi: 10.3390/ijms22042068

Figure 1.

Figure 1

Effects of AdipoRon on rodent behaviors. Administration of AdipoRon at a low dose (20 mg/kg) and high dose (50 mg/kg) for two weeks did not affect (A) locomotor activity and (B) mean speed traveled in the open field. Both dosages did not affect anxiety-like behaviors as indicated by (C) the percentage time spent at the center, (D) the number of vertical rears, and (E) the number of fecal boli in the open field. However, treatment with 50 mg/kg AdipoRon (high dose) impaired spatial recognition memory, as indicated by (F) reduced exploration index in the Y-maze task. The results were expressed as the mean ± SEM. n = 7 per group, ** p < 0.005 compared to the vehicle treated control.