Table 3.
Diagnostic accuracy for presepsin, qSOFA, SIRS, presepsin ± qSOFA, and presepsin ± SIRS in sepsis patients
| 95%CI | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| AUC | p–value | LL | LL | Cutoff # | Sensitivity | Specificity | PPV | NPV | |
| Presepsin | 0.848 | <0.001* | 0.727 | 0.968 | >640 | 73.08 | 92.86 | 95.0 | 65.0 |
| qSOFA | 0.652 | 0.116 | 0.472 | 0.833 | ≥2 | 38.46 | 78.57 | 76.92 | 40.74 |
| SIRS | 0.670 | 0.079 | 0.495 | 0.846 | ≥2 | 69.23 | 57.14 | 75.0 | 50.0 |
| Presepsin ± qSOFA | 0.838 | <0.001* | 0.715 | 0.961 | – | 76.92 | 78.57 | 86.96 | 64.71 |
| Presepsin ± SIRS | 0.849 | <0.001* | 0.729 | 0.969 | – | 80.77 | 71.43 | 84.0 | 66.67 |
#
Cutoff was done by using Youden index;
*
Statistically significant at p ≤ 0.05; AUC, area under the curve; LL, lower limit; UL, upper limit; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval; qSOFA, quick sequential organ failure assessment; SIRS, systemic inflammatory response syndrome