Table 4.

Agreement (sensitivity, specificity) for presepsin, qSOFA, SIRS, presepsin + qSOF, and presepsin + SIRS for prediction of ICU mortality

			95%CI
	AUC	p–value	LL	UL	Cutoff #	Sensitivity	Specificity	PPV	NPV
Presepsin	0.920	<0.001*	0.838	1.00	>640	100.0	66.67		100.0
qSOFA	0.670	0.111	0.469	0.871	≥2	60.0	76.67	46.15	85.19
SIRS	0.540	0.708	0.357	0.723	≥2	70.0	43.33	29.17	81.25
Presepsin + qSOFA	0.917	<0.001*	0.833	1.00	–	50.0	93.33	71.43	84.85
Presepsin + SIRS	0.920	<0.001#	0.838	1.00	–	50.0	93.33	71.43	84.85

^#Cutoff was done by using Youden index;

^*Statistically significant at p ≤ 0.05; AUC, area under the curve; LL, lower limit; UL, upper limit; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval; qSOFA, quick sequential organ failure assessment; SIRS, systemic inflammatory response syndrome