Table 4.

Biological effects of olive leaf extracts (OLEs).

Disease	Type of Experiment	Dose	Effects
Hypertension [100]	Human clinical trial	1000 mg OLE/die	Lowering systolic and diastolic blood pressures, significant reduction of triglyceride (TG) levels.
Atherosclerosis [107]	in vivo	100 mg OLE/kg body weight	Reduction of the levels of cholesterol, TGs, and LDL cholesterol, and block of the inflammatory response.
Thrombosis [109]	in vitro	1% v/v OLE	Significant dose-dependent reduction in platelet activity.
Hypocholesterolemia [111]	Human studies	1.2 g OLE/die	Reduction of total cholesterol, decreased LDL cholesterol.
Diabetes [106,108]	in vitro	IC50 = 4.0–0.02 mg/mL OLE	Inhibition of the activities of α-amylases from human saliva and pancreas.
	Human clinical trial	500 mg OLE/die	Significant reduction in HbA1C values.
Alzheimer [110]	in vivo	50 mg OLE/kg	Reduction of amyloid plaque deposition in cortex and hippocampus.
Upper respiratory illness [112]	Randomized controlled trials	100 mg oleuropein/die	Reduction of the sick days, i.e., acceleration of the recovery.