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ZnPP release from HA-es-ZnPP at different conditions. In sodium phosphate buffer, almost no ZnPP was released from the conjugate at both physiological pH and weak acidic pH up to 12 h. Much rapid release of ZnPP occurred in presence of either esterase or FBS having esterase activities. A relatively high level of ZnPP release was also found in tumor homogenate.
