. 2021 Feb 19;8(2):21. doi: 10.3390/jcdd8020021

Table 1.

Summary of the genetic tools and findings of papers describing the zebrafish cardiac lymphatic system.

	Vivien et al. [60]	Harrison et al. [33]	Gancz et al. [34]
Cardiac lymphatic vessels (LVs)	prox1a⁺ lyve1b⁺	prox1a⁺ flt4⁺ lyve1b⁺ (high BA; low ventricle) mrc1a⁺ stab1⁺	prox1a⁺ flt4⁺ lyve1b⁺ mrc1a⁺
LVs in regeneration (cryoinjury)	prox1a⁺	prox1a⁺ flt4⁺ lyve1b⁺(low) mrc1a⁺	prox1a⁺ flt4⁺ lyve1b⁺ mrc1a⁺
Roles of LVs	Cardiac hypertrophy, metabolic homeostasis, and inflammation resolution	Cardiac regeneration, cell debris clearance and inflammation resolution	Cardiac regeneration
Mutants lacking BA LECs	vegfc^hy ⁻ ^/ ⁻ ; vegfd ⁻ ^/ ⁻	-	flt4 ⁻ ^/ ⁻
Mutants/Tg lacking ventricular LECs	vegfc^hy+/−; vegfd^−/− vegfc^hy ⁻ ^/ ⁻ ; vegfd^+/−	sFlt4 cxcr4a^−/− (majority)	vegfc^+/−, flt4^−/− cxcr4a^−/− (isolated LECs unaffected)
Mutants with hypertrophy	vegfc^hy ⁻ ^/ ⁻ ; vegfd ⁻ ^/ ⁻	-	-
Mutants/Tg defective scar resolution	vegfc^hy⁻^/⁻; vegfd⁻^/⁻ (30%)	cxcr4a^−/− sFlt4	vegfc^hy−/−; vegfd^−/−, flt4^−/− cxcr4a ⁻ ^/ ⁻