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. 2021 Feb 19;9(2):176. doi: 10.3390/vaccines9020176

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic linear representation of the nascent HIV-1 Envelope (Env) protein attached to the HIV-1 signal peptide (SP). (Top) Regions corresponding to SP, glycoprotein 120 (gp120), and glycoprotein 41 (gp41) are indicated. Variable and constant regions of gp120 are indicated by V1-V5 and C1-C5, respectively. SP cleavage site is indicated by an arrow. (Bottom) Expanded schematic representation of the HIV-1 SP. The N-terminal hydrophilic positively charged region is shown in red, the central hydrophobic region is shown in green, and the slightly polar C-terminal region is shown in blue.