Table 3.

Univariate and multivariate analysis of progression-free survival.

Characteristics	Univariate Analysis		Multivariate Analysis
	HR (95%CI)	p-Value	HR (95%CI)	p-Value
Age, years (≥65)	1.41 (0.66–2.99)	0.373	-
Gender (female)	0.91 (0.34–2.39)	0.842	-
Smoking history (current or former)	1.20 (0.57–2.54)	0.625	-
Histopathology (clear cells)	2.22 (0.88–5.58)	0.089	2.09 (0.72–6.02)	0.173
Skin toxicity (present)	0.33 (0.11–0.95)	0.041	0.36 (0.12–1.06)	0.065
Thyroid disfunction (present)	0.36 (0.15–0.89)	0.028	0.34 (0.13–0.87)	0.025
Number of irAEs (≥2)	0.33 (0.13–0.81)	0.016	0.32 (0.13–0.79)	0.014

HR = hazard ratio; CI = confidence interval; irAEs = immune-related adverse events.