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. 2021 Feb 17;22(4):1989. doi: 10.3390/ijms22041989

Figure 3.

Figure 3

Cancer and oncogene correlations in OBF vs. CTRL conditions. (A) Dotplot of deregulated oncogenic pathways from KEGG analysis. The y-axis represents the name of the pathway, the x-axis represents the gene ratio, dot size represents the number of different genes and the color indicates the adjusted p-value. (B) Relationship between DE RNAs and the possibility of a cancer diagnosis. Nodes are DE RNAs and are ranked according to fold change whereas edges indicate disease prognosis and are colored according to favorable (light blue) and unfavorable (orange) prognosis. (C) Pie graph displays the overall unfavorable or favorable prognosis. (D) Co-interaction network between lncRNAs in OBF vs. CTRL and the oncogenes highlighted after OncoScore analysis. Light blue nodes are coding genes whereas pink nodes are lncRNAs. The coding and non-coding RNAs form 4 main networks of interaction, the largest of which includes both COL4A2-AS2 and SMIM25. On the contrary, ITGB2-AS1, LINC0194 (CTEPHA1) and AL121832.2 (RPS21-AS) formed each one separate interaction network. (E) The GEPIA2 database displays the specific annotated expression of each lncRNA in tumoral and normal tissues.