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. 2021 Feb 17;22(4):1989. doi: 10.3390/ijms22041989

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cancer pathways and oncogene analysis in OBT2D vs. CTRL condition. (A) Dotplot of deregulated oncogenic pathways from KEGG analysis. The y-axis represents the name of the pathway, the x-axis represents the gene ratio, dot size represents the number of different genes and the color indicates the adjusted p-value. (B) Correlation network highlights the relationship between DE RNAs and the possibility of a cancer diagnosis. Nodes are DE RNAs and are ranked according to fold change whereas edges indicate disease prognosis and are colored according to favorable (light blue) and unfavorable (orange) prognosis. (C) Pie graph displays the overall unfavorable or favorable prognosis. (D) Co-interaction network between lncRNAs on OBT2D vs. CTRL and the oncogenes highlighted after OncoScore analysis. Light blue nodes are coding genes whereas pink nodes are lncRNAs. (D) The GEPIA2 database displays the specific annotated expression of each lncRNA in tumoral and normal tissues.