Table 5.
Prognosis score and number of deregulated genes associated with each specific cancer. Unfavorable or favorable prognosis was assessed according to orange or blue edges, respectively. Upregulated or downregulated genes were described according to their log2FC. A bibliographic search was performed to assess previous correlations of each cancer type with obesity and/or T2D.
| Cancer | Unfavourable Prognosis | Favourable Prognosis | Literature Evidence | ||
|---|---|---|---|---|---|
| Upregulated Unfavourable Prognosis | Downregulated Favourable Prognosis | Downregulated Unfavourable Prognosis |
Upregulated Unfavourable Prognosis |
||
| Ovarian Cancer | 1 | 2 | 1 | 2 | Positively correlated with obesity and diabetes [36,58] |
| Thyroid Cancer | 0 | 0 | 2 | 0 | Positively correlated in obesity [37,38]; negatively correlated in diabetes [59,60] |
| Colorectal Cancer | 0 | 1 | 1 | 0 | Positively correlated with obesity and diabetes [39,61] |
| Breast Cancer | 0 | 2 | 0 | 0 | Positively correlated with obesity and diabetes [7,41,62,63] |
| Cervical Cancer | 3 | 0 | 0 | 1 | Positively correlated with obesity and diabetes [8,42,64] |
| Pancreatic Cancer | 6 | 2 | 0 | 1 | Positively correlated with obesity and diabetes [44,45,46] |
| Melanoma | 0 | 0 | 1 | 0 | Positively correlated with obesity and diabetes [46,66] |
| Head and Neck Cancer | 0 | 0 | 1 | 1 | Positively correlated with obesity and diabetes [47,67,68] |
| Lung Cancer | 1 | 1 | 1 | 0 | Negatively correlated with obesity and diabetes [48,69] |
| Renal Cancer | 14 | 3 | 12 | 2 | Positively correlated with obesity and diabetes [49,70] |
| Liver Cancer | 3 | 1 | 6 | 0 | Positively correlated with obesity and diabetes [50,71] |
| Urothelial Cancer | 0 | 0 | 2 | 1 | Positively correlated in men both in obesity and diabetes [51,72] |
| Endometrial Cancer | 3 | 1 | 1 | 2 | Positively correlated with obesity and diabetes [52,64] |