Table 3.
Perioperative characteristics of HCC patients aged ≥ 70 years stratified according to G8 score change.
| Variables | Reduction (n = 30) |
Maintenance (n = 70) |
P |
|---|---|---|---|
| Age, years | 77 (73.0, 84.2) | 77 (71.0, 87.6) | 0.677 |
| Sex | |||
| male/female | 24 (80%)/6 (20%) | 51 (73%)/19 (27%) | 0.614 |
| Diabetes | |||
| absent/present | 22 (73%)/8 (27%) | 48 (69%)/22 (31%) | 0.812 |
| Esophageal and/or gastric varices | |||
| absent/present | 28 (93%)/2 (7%) | 64 (91%)/6 (9%) | 1.000 |
| HBsAg | |||
| negative/positive | 26 (87%)/4 (13%) | 60 (86%)/10 (14%) | 1.000 |
| HCVAb | |||
| negative/positive | 16 (53%)/14 (47%) | 44 (63%)/26 (37%) | 0.504 |
| Child–Pugh class | |||
| A/B | 29 (97%)/1 (3%) | 67 (96%)/3 (4%) | 1.000 |
| ICGR15, % | 16.4 (8.7, 49.1) | 18.1 (7.0, 36.1) | 0.896 |
| WBC count, 102/μL | 46 (32.2, 76.6) | 47 (23.4, 80.1) | 0.523 |
| Hemoglobin level, g/dL | 13.2 (10.8, 15.3) | 13.05 (10.6, 15.7) | 0.863 |
| Platelet count, ×104/mm3 Pre | 17.3 (8.1, 25.9) | 15.1 (7.5, 26.1) | 0.177 |
| POM6 | 13.8 (5.6, 28.0) | 14.3 (7.3, 20.9) | 0.842 |
| Serum albumin level, g/dL Pre | 3.8 (3.0, 4.6) | 4.0 (3.4, 4.6) | 0.183 |
| POM6 | 3.7 (2.3, 4.6) | 4.0 (3.2, 4.5) | 0.055 |
| Prothrombin activity, % Pre | 85.1 (60.8, 105.2) | 86.5 (61.1, 108.3) | 0.451 |
| POM6 | 81.2 (55.5, 111.3) | 84.2 (63.7, 103.9) | 0.489 |
| Serum total bilirubin level, mg/dL Pre | 0.7 (0.4, 1.6) | 0.8 (0.4, 1.3) | 0.288 |
| POM6 | 0.8 (0.5, 2.2) | 0.8 (0.5, 1.4) | 0.612 |
| Creatinine level, mg/dL | 0.79 (0.6, 1.1) | 0.775 (0.6, 1.1) | 0.857 |
| Alpha-fetoprotein level, ng/mL Pre | 25.5 (2.2, 19303.2) | 9.1 (2.0, 369.7) | 0.044 |
| POM6 | 5.6 (2.3, 152.4) | 3.8 (2.0, 23.7) | 0.017 |
| PIVKA-II level, mAU/mL Pre | 147.5 (14.4, 48583.8) | 64 (13.0, 17661.0) | 0.299 |
| POM6 | 19.0 (8.0, 706.1) | 18.0 (11.0, 78.8) | 0.719 |
| Geriatric Depression Scale score | |||
| <3/≥3 | 12 (43%)/16 (57%) | 34 (50%)/34 (50%) | 0.680 |
| Charlson Comorbidity Index | |||
| <4/≥4 | 15 (54%)/13 (46%) | 32 (46%)/38 (54%) | 0.632 |
| Vitality index | |||
| <10/≥10 | 3 (11%)/24 (89%) | 15 (23%)/51 (77%) | 0.318 |
| G8 score | |||
| <13/≥13 | 6 (20%)/24 (80%) | 28 (40%)/42 (60%) | 0.088 |
| Tumor number | |||
| 1/2/≥3 | 25 (83%)/3 (10%)/2 (7%) | 55 (79%)/7 (10%)/8 (11%) | 0.921 |
| Tumor size, cm | 4.3 (0.7, 12.0) | 3 (1.1, 8.1) | 0.026 |
| Degree of differentiation | |||
| well/moderate/poor or necrotic | 7 (23%)/22 (73%)/1 (3%) | 13 (19%)/53 (76%)/4 (6%) | 0.922 |
| Vascular invasion | |||
| absent/present | 9 (30%)/21 (70%) | 24 (34%)/46 (66%) | 0.853 |
| Surgical margin invasion | |||
| absent/present | 24 (89%)/3 (11%) | 66 (96%)/3 (4%) | 0.345 |
| Nontumor tissue | |||
| normal/chronic hepatitis or liver fibrosis / liver cirrhosis | 2 (7%)/24 (80%)/4 (13%) | 10 (14%)/45 (64%)/15 (21%) | 0.364 |
| Tumor stage | |||
| I/II/III/IVa | 2 (7%)/10 (33%)/13 (43%)/5 (17%) | 3 (4%)/33 (47%)/30 (43%)/4 (6%) | 0.241 |
| Operative procedure | |||
| anatomical resection/non-anatomical resection | 16 (53%)/14 (47%) | 39 (56%) / 31 (44%) | 1.000 |
| Extent of hepatic resection | |||
| ≥2 sections/<2 sections | 10 (33%)/20 (67%) | 18 (26%)/52 (74%) | 0.593 |
| Operating time, min | 332 (179, 552) | 307 (159, 492) | 0.442 |
| Operative blood loss, mL | 815 (103, 1776) | 634 (58, 1543) | 0.119 |
| Blood transfusion | |||
| absent/present | 24 (80%)/6 (20%) | 64 (91%)/6 (9%) | 0.175 |
| Complications | |||
| absent/present | 24 (80%)/6 (20%) | 58 (83%)/12 (17%) | 0.955 |
Data are shown as n (%) or median (5th percentile, 95th percentile). HBsAg: hepatitis B surface antigen; HCV Ab: hepatitis C virus antibody; ICGR15: indocyanine green retention rate at 15 minutes; WBC: white blood cell; POM: post-operative month; PIVKA-II; protein induced by vitamin K absence-II.