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Anti-tumor compounds such as curcumin, cantharidin, and matrin target miRNAs in affecting the PTEN/PI3K/Akt axis in breast cancer therapy. Long non-coding RNAs (LncRNAs) such as PTENP1 and growth arrest-specific transcript 5 (GAS5) function as the main upstream mediators of the miRNA/PTEN axis in breast cancer.
