Table 2.

miRNAs inhibiting PTEN expression in enhancing lung cancer progression.

miRNA	Signaling Network	Outcomes	Refs
miRNA -93	LKB1/PTEN/CDKN1A/PI3K/Akt	Upregulation of miRNA-93 in lung cancer cells Association with proliferation and metastasis of cancer cells Inhibiting LKB1/PTEN/p21 axis Inducing PI3K/Akt	[171]
miRNA -21	PTEN/EMT	Reverse relationship with PTEN Promoting metastasis via EMT induction	[172]
miRNA -21	PTEN/Akt/GSK-3b	Increasing cyclin D1 and cyclin E1 expressions Enhancing cancer cell proliferation Promoting metastasis via EMT induction Activating Akt/GSK-3b signaling via PTEN downregulation	[173]
miRNA -21	-	Enhancing cell proliferation and invasion Apoptosis inhibition PTEN inhibition	[174]
miRNA -26a	PTEN/Akt	Enhancing metastasis via PTEN downregulation and the subsequent induction of Akt signaling	[175]
miRNA -21	-	Binding to 3′-UTR of PTEN Reducing the mRNA level of PTEN Promoting growth and metastatic features	[176]
miRNA -205	PTEN/Akt/mTOR	PTEN inhibition Activating Akt/mTOR signaling Increasing malignancy of lung cancer cells	[177]
miRNA -183-5p	PTEN/Akt/p53	Exerting oncogenic role Promoting Akt phosphorylation via PTEN downregulation Activating p53	[178]