Table 3.
miRNAs regulating PTEN signaling in breast cancer chemotherapy.
| miRNA | Chemotherapeutic Agent | Impact on Chemotherapy | Remarks | Refs. |
|---|---|---|---|---|
| miRNA -93 | Doxorubicin | Resistance | PTEN downregulation EMT induction Increasing cancer metastasis and malignancy |
[209] |
| miRNA -202-5p | Doxorubicin | Resistance | Enhancing tumor volume and progression Downregulating PTEN and subsequent induction of PI3K/Akt signaling |
[107] |
| miRNA -222 | Adriamycin | Resistance | Activation of PI3K/Akt signaling via PTEN downregulation Association with poor prognosis |
[203] |
| miRNA -222 | Adriamycin | Resistance | PTEN downregulation Inducing Akt signaling P27 inhibition Triggering the resistance of cancer cells to apoptosis |
[191] |
|
miRNA
-222
miRNA -29a |
Adriamycin Doxorubicin |
Resistance | Overexpression in drug-resistant cancer cells Association with PTEN downregulation |
[204] |
| miRNA -520h | Paclitaxel | Resistance | Binding to OTUD3 and reducing its expression PTEN inhibition Paving the way for Akt induction |
[212] |
| miRNA -221/222 | Cisplatin | Resistance | Downregulation of miRNA-221/222 enhances cisplatin sensitivity Activation of p53/PTEN signaling following miRNA inhibition |
[211] |