Table 3.

Glutamate, lactate, total NAA and total creatine concentration estimates and relative changes from baseline in pons of patients who experienced migraine attacks.

	Baseline mean mmol/L ± SE	Attack mean mmol/L ± SE	Change from baseline (mean)	Effect estimate and 95% CI	p	CGRP vs. sildenafil: Effect estimate and 95% CI	CGRP vs. Sildenafil: P
Glutamate	8.30 ± 0.19	8.33 ± 0.19	0.9%	0.03, –0.35–0.41	0.873	0.18, –0.58–0.93	0.654
Total creatine	4.57 ± 0.09	4.73 ± 0.08	3.5%	0.16, 0.01–0.31	0.041	0.22, –0.07–0.50	0.145
Total NAA	10.30 ± 0.12	10.63 ± 0.13	3.5%	0.34, 0.08–0.60	0.014	0.12, –0.41–0.63	0.678
Lactate	0.93 ± 0.08	0.78 ± 0.09	–6.3%	–0.16, –0.34–0.30	0.099	–0.05, –0.42–0.31	0.778

Note: Three baseline lactate values after CGRP and one post drug (including baseline) value after sildenafil were excluded according to protocol as described in ‘Materials and Methods’ section. Absolute mean and standard error of the mean (SE) reported from mixed model.

CI: confidence interval; NAA: N-acetylaspartate.