Table 1.
Published case series about murine typhus in pregnancy (1992–2020).
| STUDY INFORMATION | ||||||||
|---|---|---|---|---|---|---|---|---|
| Author-Year | Graves-1992 | Koliou-2007 | Gutierrez-2010 | Jolley-2010 | McGready-2010 | Chansamouth-2016 | Tanabe-2019 | Stafford-2020 |
| Location (Country) | Australia | Cyprus | USA | USA | Thai-Burmanese border | Laos | USA | USA |
| Number of patients | 1 | 1 | 1 | 1 | 14 | 15 | 2 | 2 |
| MATERNAL HEALTH | ||||||||
| Age (mean/range) | 17 | 30 | 26 | 33 | 27 (16–36) | 28 (20–36) | 29 (24–34) | |
| Gestational Age (mean/range) | 23 | 30 | 26 | 32 | 21 (7–39) | 39 (35–40) | 21 (12–30) | 22 (13–31) |
| Maternal comorbidities (n) ** | ✕ | ✕ | ✓ (5) | ✓ (5) | ✓ (1) | ✕ | ||
| Prior pregnancies (n) | ✕ | ✕ | ✕ | ✓ (11) | ✓ (1) | ✓ (1) | ||
| Risk factor for MT | cats, opposums | cats | pets and fleas | |||||
| CLINICAL COURSE | ||||||||
| Headache (n) | ✓ | ✓ | ✓ | ✓ | ✓ (13) | ✓ (2) | ✓ (2) | |
| Rash (n) | ✓ | ✓ | ✕ | ✓ | ✕ | ✓ (1) | ✓ (1) | |
| Fever (n) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ (2) | ✓ (2) | |
| Transaminitis (n) | ✓ | ✓ | ✓ | ✓ | ✓ (2) | ✓ (2) | ||
| Hyponatremia (n) # | ✕ | ✕ | ✓ | ✓ (2) | ✕ | |||
| Thrombocytopenia (n) | ✓ | ✕ | ✕ | ✓ | ✓ (2) | ✓ (1) | ||
| Diagnosis | serology | serology | serology | serology | serology, PCR | serology, PCR | serology | microbial cell-free DNA |
| Treatment | erythromycin | erythromycin | ampicillin | azithromycin | azithromycin | azithromycin | azithromycin, doxycycline | azithromycin, doxycycline |
| FETUS HEALTH | ||||||||
| Born at term (n) *** | ✓ (1) | ✓ (1) | ✓ (1) | ✓ (1) | ✓ (10) | ✓ (8) | ✓ (2) | ✓ (1) |
| Poor outcome (n) * | ✕ | ✕ | ✕ | ✕ | ✓ (4) | ✓ (2) | ✕ | ✕ |
| REFERENCE | 11 | 12 | 13 | 14 | 15 | 16 | n/a | 17 |
Footnote: ✓: present ✕: absent.* Poor outcome: stillborn, abortion, prematurity (<35 weeks), and fetal growth restriction (birth weight < 10th percentile). ** Comorbidities: diabetes mellitus, hypertension, substance abuse, tobacco use, co-infections, dyslipidemia, heart disease, eclampsia/preeclampsia. *** TERM: 37–42 weeks. # Hyponatremia < 134 meq/dL, Absolute thrombocytopenia PLT < 150,000 cells/cm3, Transaminitis ALT > ULN (40). (BLANK): Information not given. The table was filled based on the best information provided by the article. Totals do not equal 100% as some patients’ data were missing.